| 內容 | Research interests:
Insect Pathology, Insect Biotechnology and RNAi
E-mail: runwu@ntu.edu.tw
Lab: Insect Pathology Laboratory
Tel: +886-2-3366-5528
Education:
Ph. D. Institute of Biotechnology (09/2001-06/2008), National Cheng Kung University, Tainan, Taiwan.
M.S. Department of life science (09/1999-07/2001). National Central University, Taoyuan, Taiwan.
B.S. Department of Forestry and Nature Conservation (09/1995-07/1999). Chinese Culture University, Taipei, Taiwan.
Professional experience:
2022-present Professor, Department of Entomology, National Taiwan University.
2019-2022 Associate professor, Department of Entomology, National Taiwan University.
2013-2019 Assistant professor, Department of Entomology, National Taiwan University.
2008-2013 Postdoctoral Fellow, Institute of Molecular Biology, Academia Sinica, Taiwan.
2017 (6 mo) Visiting scholar, Department of Entomology, University of Georgia, GA, USA.
2019 Editorial Board Member, Scientific reports
Current research are as follows:
- We are exploring the possibility of using miRNAs to control lepidopteran pests.Our study results show that miRNAs can regulate viral infection cycles and increase susceptibility of lepidopteran pests such as cotton bollworms.This finding indicates that miRNAs can potentially replace traditional pesticide control methods for overcoming existing resistance issues and for improving agricultural environments.
- We are seeking a pharmaceutical approach to protect honeybee from the immune and neurological damages caused by pathogens. Our lab discovered that expression levels of genes associated to immunity, learning and memory were significantly increased following treating with histone deacetylase inhibitors (HDACi). Such transcriptional modulation by HDACi treatment also facilitated bee recovering from the cellular damages caused by pathogenic infection. We are currently assessing to apply our findings to the beekeeping industry.
Key publications:
Refereed Publications (last 5 years)
- Pei-Chi Wu, Yu-Hsien Lin, Song-Tay Lee, Carol-P Wu, Tsai-Chin Wu, Yuan Chang and Yueh-Lung Wu*. 2018. MicroRNAs derived from the insect virus HzNV-1 promote lytic infection by suppressing histone methylation. Scientific Reports.8, Article number: 17817. (5-yr IF=4.609, 12/64 (18.7%) in Multidisciplinary Sciences).
- Yee-Tung Hu, Pei-Chi Wu, Cheng-Kang Tang, En-Cheng Yang and Yueh-Lung Wu*. 2018. Histone deacetylase inhibitor-treatment restores memory-related gene expression and learning ability in neonicotinoid-treated Apis mellifera. Insect Molecular Biology.Aug;27(4):512-521.(5-yr IF=2.81, 10/96 (10%) in Entomology).
- Yu-Wei Chen, Carol-P Wu, Tsai-Chin Wu and Yueh-Lung Wu*. 2018. Analyses of the transcriptome of Bombyx mori cells infected with either BmNPV or AcMNPV. Journal of Asia-Pacific Entomology. 21. 37-45. (5-yr IF=0.98, 60/96 (62.5%) in Entomology)
- Yee-Tung Hu, Tsai-Chin Wu, En-Cheng Yang, Pei-Chi Wu and Yueh-Lung Wu*. 2017. Regulation of genes related to immune signaling and detoxification in Apis mellifera by an inhibitor of histone deacetylation. Scientific Reports. 7: article 41255.(5-yr IF=4.609, 12/64 (18.7%) in Multidisciplinary Sciences)
- Chang KP.,Batchu R,Chen HW,Chow LC,Elliott R,Head J,Fan CK,Hung CH,Ji DD,Lun ZR,Manna L,Matsumoto Y,Ng DP,de Oliveira C,Melo S,Ozbel Y,Özbilgin A,Reynolds J,Sanjoba C,Shiao SH,Shih NY,Tsai CW,Vicente MG,Barré C,Volf P,Wu YL,Yu CL,Zhou XN.Kolli BK. 2016. New "light" for one-world approach toward safe and effective control of animal diseases and insect vectors from leishmaniac perspectives. Parasites & Vectors. Jul 13;9(1):396. (5-yr IF=3.408, 6/37 (16.2%) in Parasitology).
- Yueh-Lung Wu, Carol-P Wu, Yu-Hui Huang, Sheng-Ping Huang, Hue-Ru Lo, Hao-Shuo Chang, Pi-Hsiu Lin, Ming-Cheng Wu, Chia-Jung Changand Yu-Chan Chao*. 2014. Identification of a high efficiency baculovirus DNA replication origin that functions in insect and mammalian cells. Journal of Virology. 88:13073-85. (Selected as the Spotlight paper by the Journal) (5-yr IF=4.13, 8/35 (22.8%) inVirology)
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