Department of Entomology, National Taiwan University

Research interests:

Insect Pathology, Insect Biotechnology and RNAi

E-mail: runwu@ntu.edu.tw

Lab: Insect Pathology Laboratory

Tel: +886-2-3366-5528

Education:

Ph. D. Institute of Biotechnology (09/2001-06/2008), National Cheng Kung University, Tainan, Taiwan.

M.S. Department of life science (09/1999-07/2001). National Central University, Taoyuan, Taiwan.

B.S. Department of Forestry and Nature Conservation (09/1995-07/1999). Chinese Culture University, Taipei, Taiwan.

Professional experience: 

2022-present Professor, Department of Entomology, National Taiwan University.

2019-2022 Associate professor, Department of Entomology, National Taiwan University.

2013-2019 Assistant professor, Department of Entomology, National Taiwan University.

2008-2013 Postdoctoral Fellow, Institute of Molecular Biology, Academia Sinica, Taiwan.

2017 (6 mo)  Visiting scholar, Department of Entomology, University of Georgia, GA, USA. 

2019    Editorial Board Member, Scientific reports  

Current research are as follows:

1. We are exploring the possibility of using miRNAs to control lepidopteran pests.Our study results show that miRNAs can regulate viral infection cycles and increase susceptibility of lepidopteran pests such as cotton bollworms.This finding indicates that miRNAs can potentially replace traditional pesticide control methods for overcoming existing resistance issues and for improving agricultural environments. 
2. We are seeking a pharmaceutical approach to protect honeybee from the immune and neurological damages caused by pathogens. Our lab discovered that expression levels of genes associated to immunity, learning and memory were significantly increased following treating with histone deacetylase inhibitors (HDACi). Such transcriptional modulation by HDACi treatment also facilitated bee recovering from the cellular damages caused by pathogenic infection. We are currently assessing to apply our findings to the beekeeping industry.

Publications:

1. Yao-Kuang Tseng, Yun-Heng Lu, Yun Liu, Zhi-Wei Weng, Yu-Tzu Lin, Chih-Hsuan Tsai, Rong-Nan Huang and Yueh-Lung Wu* (2025, Apr). A Novel Chitin-Based Purification System Using GAL1 Fusion Tags: Enhancing Recombinant Protein Production While Retaining Biological Activity. Microbial Biotechnology. (Accepted). *Corresponding Author. (SCI; 5y IF:6.4, 21/159=13% (BIOTECHNOLOGY & APPLIED MICROBIOLOGY))
2. Yu-Chun Lin, Yun-Heng Lu, Yun Liu, Yu-Juan Su, Yu-Hsien Lin and Yueh-Lung Wu* (2025, Apr). Differential RNAi efficacy of siRNA and dsRNA targeting key genes for pest control in Spodoptera litura. Frontiers in Insect Science, 10.3389/finsc.2025.1574585. *Corresponding Author. (SCI; 5y IF:2.4, 18/109=16.5% (ENTOMOLOGY))
3. Chia-Yang Lin; Yu-Chun Lin; Yun-Heng Lu; Shiang-Jiuun Chen; Lin Yu-Hsien; Yao-Kuang Tseng; Yu-Tzu Lin; Rong-Nan Huang* and Yueh-Lung Wu* (2024, Dec). Synergistic impacts of propargite exposure and deformed wing virus infection on the health of western honey bees. Ecotoxicology and Environmental Safety, Volume 289, 1 January 2025, 117430. NSTC 111-2313-b-002-038-my3. *Corresponding Author. (SCI; 5y IF:6.9, 7/94=7% (TOXICOLOGY))
4. Sheng-Hao Chen, Jen-Cheng Wang, Hung-Jen Lin, Mu-Hwa Lee, An-Chi Liu, Yueh-Lung Wu, Pei-Shou Hsu, En-Cheng Yang, Joe-Air Jiang (2024, Dec). A machine learning-based multiclass classification model for bee colony anomaly identification using an IoT-based audio monitoring system with an edge computing framework. Expert Systems with Applications, Volume 255, Part D , 1 December 2024, 124898.
5. Silke Allmann, Yu-Hsien Lin, Juliette Silven, Nicky Wybouw, Richard Fandino, Henk Dekker, Heiko Vogel, Yueh-Lung Wu, Chris de Koster, Ewald Große- Wilde, Michel Haring, and Robert Schuurink (2023, May). A salivary GMC oxidoreductase of Manduca sexta re-arranges the green leaf volatile profile of its host plant. Nature Communications. (SCI; 5y IF:17.764, 5/74=6.76% (MULTIDISCIPLINARY SCIENCES)) .
6. Yu-Chun Lin, Yun-Heng Lu, Cheng-Kang Tang, En-Cheng Yang and Yueh-Lung Wu* (2023, May). Honey bee foraging ability suppressed by imidacloprid can be ameliorated by adding adenosine. Environmental Pollution. (Accepted). *Corresponding Author. (SCI; 5y IF:10.0366, 28/279=9.9% (ENVIRONMENTAL SCIENCES))
7. Peter Kmet, Lucie Kucerova, Hana Sehadova, Bulah Chia-hsiang Wu, Yueh-Lung Wu, Michal Zurovec*. Identification of silk components in the bombycoid moth Andraca theae (Endromidae) reveals three fibroin subunits resembling those of Bombycidae and Sphingidae.  Journal of Insect Physiology. https://doi.org/10.1016/j.jinsphys.2023.104523. (SCI; IF: 2.608, 24/100=24%(ENTOMOLOGY))  
8. Yun Kuo, Yun-Heng Lu, Yu-Hsien Lin, Yu-Chun Lin, and Yueh-Lung Wu^* (2023, Mar). Elevated temperature affects energy metabolism and behavior of bumblebees. Insect Biochemistry and Molecular Biology. (Accepted). *Corresponding Author. (SCI; IF: 4.429, 9/100=9%(ENTOMOLOGY))
9. Chia-Yang Lin, Yu-Hsien Lin, Yu-Chun Lin, Chun-Min Hsu, Yueh-Lung Wu^* and Rong-Nan Huang*(co-corresponding author) (2022, Oct). Enhancing the insecticidal potential of a baculovirus by overexpressing the mammalian β- galactosyl binding protein galectin-1. Pest Management Science. nstc 110-2313- b-002-005. https://doi.org/10.1002/ps.7237. *Corresponding Author. (SCI; IF: 4.463, 8/100=8% (ENTOMOLOGY))
10. Chih-Hsuan Tsai, Yi-Chi Chuang, Yun-Heng Lu, Chia-Yang Lin, Cheng-Kang Tang, Sung-Chan Wei and Yueh-Lung Wu^*.2022. Carbohydrate metabolism is a determinant for the host specificity of baculovirus infections. iScience. Vol 25, Issue 1. *Corresponding Author. (SCI; IF: 5.458, 14/73=19.1% (MULTIDISCIPLINARY SCIENCES))
11. Ping Chen, Yun-Heng Lu, Yu-Hsien Lin, Carol-P Wu, Cheng-Kang Tang, Sung-Chan Wei and Yueh-Lung Wu^*. 2021. Deformed wing virus infection affects the neurological function of Apis mellifera by altering extracellular adenosine signaling. Insect Biochemistry and Molecular Biology. (Accepted) *Corresponding Author. (SCI; IF: 4.714, 7/102=6.8% (ENTOMOLOGY))
12. Cheng-Kang Tang, Yu-Hsien Lin, Joe-Air Jiang, Yun-Heng Lu, Chih-Hsuan Tsai, Yu-Chun Lin, Yun-Ru Chen, Carol-P Wu, and Yueh-Lung Wu^*. 2021. Real-time monitoring of deformed wing virus-infected bee foraging behavior following histone deacetylase inhibitor treatment. iscience. Vol 24, Issue 10. *Corresponding Author. (SCI; IF: 5.458, 14/73=19.1% (MULTIDISCIPLINARY SCIENCES))
13. Carol P. Wu, Chia-Jung Chang, Cheng-Hsun Li and Yueh-Lung Wu^*. 2021. The influence of serial passage on the stability of an exogenous gene expression in recombinant baculovirus. Entomological Research. 51(4), p168. *Corresponding Author. (SCI; IF: 1.306, 60/102=58.8% (ENTOMOLOGY))
14. Cheng-Kang Tang, Chih-Hsuan Tsai, Carol-P Wu, Yu-Hsien Lin, Sung-Chan Wei, Yun-Heng Lu, Cheng-Hsun Li, and Yueh-Lung Wu^*. 2021. MicroRNAs from Snellenius manilae bracovirus regulate innate and cellular immune responses of its host Spodoptera litura. Communications Biology. 4, Article number: 52 *Corresponding Author. (SCI; IF: 6.268, 8/93=8.6% (BIOLOGY))
15. Yun-Heng Lu, Carol-P Wu, Cheng-Kang Tang, Yu-Hsien Lin, Houda Ouns Maaroufi, Yi-Chi Chuang, and Yueh-Lung Wu*. 2020. Identification of Immune Regulatory Genes in Apis mellifera through the Caffeine Treatment. Insects. 11(8), 516; https://doi.org/10.3390/insects11080516. (SCI; IF: 2.769, 18/102=17.6% (ENTOMOLOGY))
16. Yu-Hsien Lin, Chia-Chi Tai, Václav Brož, Cheng-Kang Tang, Ping Chen, Carol P. Wu, Cheng-Hsun Li and Yueh-Lung Wu*. 2020. Adenosine receptor modulates permissiveness of baculovirus (budded virus) infection via regulation of energy metabolism in Bombyx mori. Frontiers in immunology. Apr; 11; 276. doi: 10.3389/fimmu.2020.00763. (SCI; IF: 7.561, 24/162=14.8% (IMMUNOLOGY))
17. Yuan Chang, Cheng-Kang Tang, Yu-Hsien Lin, Chih-Hsuan Tsai, Yun-Heng Lu and Yueh-Lung Wu*. 2020. Snellenius manilae bracovirus suppresses the host immune system by regulating extracellular adenosine levels in Spodoptera litura. Scientific Reports. Feb 7;10(1):2096. doi: 10.1038/s41598-020-58375-y. (SCI; IF: 4.379, 14/73=23.2% (MULTIDISCIPLINARY SCIENCES))
18. Jen-Fu Liao, Carol-P Wu, Cheng-Kang Tang, Chi-Wei Tsai, Lenka Rouhová and Yueh-Lung Wu*. 2019. Identification of regulatory host genes involved in sigma virus replication using RNAi knockdown in Drosophila. Insects. 10(10), 339; doi: 10.3390/insects10100339. (SCI; IF: 2.769, 18/102=17.6% (ENTOMOLOGY))
19. Pei-Chi Wu, Yu-Hsien Lin,Song-Tay Lee,Carol-P Wu, Tsai-Chin Wu, Yuan Chang and Yueh-Lung Wu*.2018. MicroRNAs derived from the insect virus HzNV-1 promote lytic infection by suppressing histone methylation. Scientific Reports. (Accepted).
20. Yee-Tung Hu, Pei-Chi Wu,Cheng-Kang Tang, En-Cheng Yangand Yueh-Lung Wu*. 2018. Histone deacetylase inhibitor-treatment restores memory-related gene expression and learning ability in neonicotinoid-treated Apis mellifera. Insect Molecular Biology.Aug;27(4):512-521.
21. Yu-Wei Chen, Carol-P Wu, Tsai-Chin Wu and Yueh-Lung Wu*. 2018. Analyses of the transcriptome of Bombyx mori cells infected with either BmNPV or AcMNPV. Journal of Asia-Pacific Entomology. 21. 37-45. 
22. Yee-Tung Hu,Tsai-Chin Wu, En-Cheng Yang, Pei-Chi Wu and Yueh-Lung Wu*. 2017. Regulation of genes related to immune signaling and detoxification inApis melliferaby an inhibitor of histone deacetylation. Scientific Reports. 7: article 41255.
23. Chang KP.,Batchu R,Chen HW,Chow LC,Elliott R,Head J,Fan CK,Hung CH,Ji DD,Lun ZR,Manna L,Matsumoto Y,Ng DP,de Oliveira C,Melo S,Ozbel Y,Özbilgin A,Reynolds J,Sanjoba C,Shiao SH,Shih NY,Tsai CW,Vicente MG,Barré C,Volf P,Wu YL,Yu CL,Zhou XN.Kolli BK. 2016. New "light" for one-world approach toward safe and effective control of animal diseases and insect vectors from leishmaniac perspectives. Parasites & Vectors. Jul 13;9(1):396. doi: 10.1186/s13071-016-1674-3. 
24. Wu, Y. L., C. P. Wu, and Y. C. Chao*. 2014. Identification of a high efficiency baculovirus DNA replication origin that functions in insect and mammalian cells. Journal of Virology. 88:13073-85. (Selected as the Spotlight paperby the Journal)
25. Wu, Y. L., C. P. Wu, C. Y. Y. Liu, W. C. Hsu, E. C. Wu, and Y. C. Chao. 2011. A non-coding RNA of HzNV-1 virus establishes latent viral infection through microRNA. Scientific Reports 1: article 60. (Scientific Reports is an, online, open access, multidisciplinary publication from Nature Publishing Group)(Impact Factor of 5.578., Journal Rankin Category=5/56).
26. Yueh-LungWu, Carol P.Wu, Catherine Y. Y. Liu, Song-Tay Lee, Hsiao-Ping Leeand Yu-Chan Chao.2011. HzNV-1 viral gene hhi1induces apoptosis which is blocked by Hz-iap2 and a non-coding gene pag1. Journal of Virology 85:6856-66. (Impact Factor of 5.308., Journal Rankin Category=3/27).
27. Carol P. Wu, Yi-Ru Huang, Jen-Yeu Wang, Yueh-Lung Wu, Huei-Ru Lo, Jui-Ching Wang, and Yu-Chan Chao.2010. AcMNPV LEF-2 is a Capsid Protein Required for Amplification but not Initiation of Viral DNA Replication. J Virol. 84: 5015-5024. (Impact Factor of 5.308., Journal Rankin Category=3/27)
28. Yueh-Lung Wu., Carol P.Wu., Song-Tay Lee., Han Tang., Chi-Hua Chang., Hong-Hwa Chen.and Yu-Chan Chao. 2010. The Early Gene hhi1 Reactivates Latent HzNV-1 Virus in the Latently Infected Cells.J Virol. 84: 1057-1065. (Impact Factor of 5.308., Journal Rankin Category=3/27)
29. Yueh-Lung Wu and Yu-Chan Chao. 2008. The establishment of a controllable expression system in baculovirus: stimulated over-expression of polyhedrin promoter by lef-2. Biotechnology Progress 24: 1232-1240. (Impact Factor of 2.389., Journal Rankin Category=16/108)
30. Yueh-Lung Wu., Catherine Y. Y. Liu., Carol P. Wu., Chia Hung Wang., Song-Tay Lee. and Yu-Chan Chao.2008. Cooperation of ie1and p35 genes in the activation of baculovirus AcMNPV and HzNV-1 promoters. Virus Research135: 247-254. (Impact Factor of 2.810., Journal Rankin Category=15/30)
31. Tsai, T. C., H. M. Yang,Y. L. Wu, C. W. Chi, M. D. Chou, L. S. Lee, and T. J. Chang. 1999. Abnormal transcripts of FHIT gene in Chinese brain tumors. Oncol. Rep. 6:345-348. (SCI) (Impact Factor of 1.524)
32. Chang, T. J., T. C. Tsai,Y. L. Wu, H. M. Yang, C. W. Chi, A. H. Yang, and C. H.Lee. 1998. Abnormal transcripts of FHIT gene in thyroid cancer. Oncol. Rep. 5:245-247. (SCI) (Impact Factor of 1.524)